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KMID : 0811720050090000068
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Korean Journal of Physiology & Pharmacology
2005 Volume.9 No. 0 p.68 ~ p.0
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Mitochondrial Calcium Transient during the Release of Histamine Induced by Beta-1,3-Glucan in Bone Marrow Mast Cells
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Cuong Dang Van
Youm Jae-Boum
Kim Na-Ri
Joo Hyun
Park Won-Sun
Kang Sung-hyun
Kim Tae-Ho
Kim Hyoung-Kyu
Kim Hyun-ju
Moon Hye-Jin
Lee Hyun-suk
Khoa Tran-Minh
Thu Vu Thi
Kim Eui-Yong
Han Jin
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Abstract
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The present study examined whether β-1,3-glucan (BG) induces histamine release and the role of calcium transients in histamine release. C57 black mouse bone marrow mast cells were challenged with BG; subsequently, histamine contents and calcium transients were measured by spectrofluorometric assay and fluorescent confocal microscopy. BG-induced histamine release from mast cells occurred in a time- and dose-dependent manner. Pretreatment with IgE inhibited BG-induced histamine release in a dose-dependent fashion. BG-induced histamine release was influenced by calcium-free conditions; A23187-induced histamine release decreased significantly. TMB-8, an intracellular calcium antagonist, dose-dependently inhibited the histamine release under these conditions. These findings suggest that BG-induced histamine release may be attributable to calcium transients.
Source: Korean Journal of Physiology & Pharmacology.2005 Oct;9(Suppl I):S89-S89
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KEYWORD
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Mast cell, Calcium, Histamine, Beta-Glucan
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